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KMID : 0377619720230060627
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Korean Jungang Medical Journal
1972 Volume.23 No. 6 p.627 ~ p.631
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Response of Spleen and Lymph Node of the Mice following Active Immunization of Living Sarcoma 180 Ascites Tumor Cells by Means of Diffusion Chamber
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Abstract
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It is a well known fact that tumor immunity is mediated by cell-mediated immune reaction and that in the cell-mediated immune reaction a small thymusdependent lymphocyte transforms into a large pyroninophilic cell at the thymusdependent area, i.e., paracortical area of the lymph node and periarterial sheath of the spleen in response to a n antigen, which will elicit either a delayed hypersensitivity reaction or an allograft rejection response (Baker et al., 1962; Parrott et al., 1966).
Littman et al. (1968) reported that a high level of immunity of a long duration against Ehrlich carcinoma was produced in CF, white Swiss mice by UV-irradiated homologous sarcoma 180 ascites tumor cells and suggested that the immunity produced by irradiated, killed tumor cell vaccine was primarily cell mediated. Cho and Kim (1972) observed a high level of immunity was produced in mice against subcutaneously implanted sarcoma 180 by intraperitoneal mounting of diffusion chamber containing living tumor cells.
In this paper an attempt was made to observe the response of thymus-dependent. area both of spleen and lymph node of the mice following active immunization with living sarcoma 180 ascites tumor cells in diffusion chamber mounted in the. peritoneal cavity.
The results were as follows:
In the immune mice, the appearance of large lymphoid cells both in the, paracortical area of the lymph node and the periarterial sheath of the spleen was prominent.
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